Adeno associated virus aav vectors are currently among the most frequently used viral vectors for gene therapy at recent meetings of the american society for gene therapy nearly half of the presentations involved the use of aav this represents a significant turnaround. Microbiology society and plan s about us shopping cart toggle navigation tools toggle navigation share personal account sign in username password login need login help sign in via shibboleth register share tools add to my favorites you must be logged in to use this functionality create content alert create correction alert. Adeno associated virus aav is a small virus that infects humans and some other primate species aav is not currently known to cause diseasethe virus causes a very mild immune response lending further support to its apparent lack of pathogenicityin many cases aav vectors integrate into the host cell genome which can be important for certain applications but can also have unwanted . Adeno associated virus aav based delivery techniques may hold the key in the simplest form translating gene therapies from conceptual design to clinical trials involve identifying a therapeutic gene finding a means to deliver it and identifying a suitable route of administration. Adeno associated viral vectors adeno associated virus aav one of the most attractive gene therapy vectors usually interacts with heparan sulfate proteoglycans on cell membrane as the first step for cellular internalization like an adenovirus it also induces strong immune responses infects both dividing and nondividing cells and remains
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